Caution: The following review includes references to graphic/offensive content.
When diagnosed with the human form of mad cow disease, Cameron is a 16-year-old with a dysfunctional family, a “whatever” attitude and a penchant for smoking pot. Facing death, Cameron takes an epic journey that allows him, for the first time, to feel something besides apathy toward his own life and other people.
Cameron’s journey begins several weeks after his diagnosis, when a punk-rock angel named Dulcie visits him at the hospital. She tells him about a scientist named Dr. X who traveled through time and space, inadvertently bringing back dark energy that is now endangering the planet and Cameron’s life. Dulcie says Cameron must go on a quest to find Dr. X. It’s the only way he can get a cure for himself and save the world. She insists that he take his hospital roommate, Gonzo, with him. Gonzo is a hypochondriac dwarf who Cameron recently met in the stoner bathroom at school. Dulcie offers little direction concerning how to find Dr. X., except to say that nothing is random and everything is connected. She says she’ll appear periodically to help, but that Cameron should seek clues in tabloids, billboards and the like.
Once Cameron and Gonzo escape from the hospital, they follow “signs” to New Orleans. A drag queen helps them find a jazz legend named Junior Webster. Junior offers advice just before he’s killed by the dark energy (which manifests itself as fire gods and their leader, the Wizard of Reckoning).
Cameron and Gonzo escape, and members of a happiness cult known as the Church of Everlasting Satisfaction and Snack-‘N’-Bowl (CESSNAB) take them in. Cameron nearly decides to stay at CESSNAB when he finds himself on the wrong side of a raid on the compound. CESSNAB erupts into chaos as members begin to think independently, and Cameron and Gonzo make their exit.
Cameron then attends a keg party with strangers. In the yard, he meets a live garden gnome named Balder who vows to assist him on his quest. After another near miss with the fire gods, Cameron, Gonzo and Balder buy a crummy used car. They take a detour through Hope, Ga., where Cameron sees Dulcie and places a wish (“to live”) on a wishing tree. They move on and stay with some scientists who study time-travel theories. The scientists try unsuccessfully to help Cameron find Dr. X.
En route to Daytona Beach, Fla., Cameron picks up three hitchhiking college guys and parties with them. After Cameron and Gonzo drop off their passengers, they realize the guys kidnapped Balder. They hunt for the yard gnome at the Party House, a Spring Break hot spot complete with TV crews filming stunt and reality shows. Cameron loses his virginity to a girl from his hometown before having sex with Dulcie. Gonzo falls for a guy named Drew, and they recover Balder by agreeing to participate in a couple of reality shows. A famous band that literally vanished years earlier reappears at the Party House. They say they’ve traveled through time and space. They use their music to help Cameron close Dr. X’s wormhole and save the planet. The dark energy traps Dulcie in a snow globe, and Cameron tries to save her.
Cameron’s hallucinations become stranger and harder to follow, and readers discover the journey has only taken place in his mind as he’s careening into madness. Cameron realizes that the Wizard of Reckoning, who has been chasing him, is really him. He has been his own worst enemy. When Cameron dies, he finds himself happy in some unexplained location with Dulcie.