Seventy years ago, scientists created a race of humans nearly impervious to disease. When this generation’s children were born, however, the genetic alterations backfired. Suddenly, all males die at age 25, all females at 20. The same thing happens to their children.
Now the wealthy search feverishly for a cure, while the poor endure rampant crime and prostitution. Many young women are kidnapped and sold into polygamous marriages. Their rich husbands use them and their children as experiments to keep the population going. This is how 16-year-old Rhine Ellery becomes a bride.
Rhine finds herself in the back of a van full of girls. She and two others are sent to a lavish mansion to marry 21-year-old Linden Ashby. The other girls are shot.
Under the watchful eye of Vaughn, who is Linden’s father, Rhine, a 13-year-old named Cecily and a 19-year-old named Jenna marry Linden. Rhine soon discovers that Vaughn is obsessed with genetic research and that Linden has no idea the brides are in his home against their will. Linden is as much a pawn in his father’s schemes as are the girls.
Rhine develops a brief friendship with Lady Rose, Linden’s dying 20-year-old wife. The many experimental medications Vaughn gives her only make her death more agonizing. When she passes, Linden is distraught and initially grieves rather than spending time with his new brides. Vaughn’s staff, including a male servant Rhine’s age named Gabriel, caters to her needs. She and her sister wives, locked on their designated floor of the mansion, read, play games and try to entertain themselves.
Cecily eagerly anticipates all things associated with marriage and childrearing. She reads endless pregnancy books and the Kama Sutra. Her enthusiasm wanes after she gets pregnant and becomes sick. Jenna, who will turn 20 the following year, figures the mansion is as good a place as any to die. She does her wifely sexual duties but remains emotionally distant from Linden.
Linden likes Rhine best. He intends for her to be his “first wife,” the one he takes to parties and social events. He often sleeps in Rhine’s bed with her but never forces himself on her physically because he knows she doesn’t want to be sexually intimate.
Rhine plays along as the first wife, thinking maybe she can escape during one of the events they attend. If any are televised, she hopes her twin brother will see her and know she’s alive. Though Rhine hates her circumstances, she still feels bad for Linden. His father has created a false life full of holograms, fake flower gardens and other lies.
Rhine’s friendship with Gabriel deepens, until Vaughn banishes him to the basement to work. Gabriel and Rhine know Vaughn conducts unseemly experiments on corpses there, including bodies of dead wives and babies he’s told Linden were cremated. When Rhine discovers a way out of the compound, she sneaks down to see Gabriel. They agree to meet and escape in a month.
Cecily has her baby. Vaughn frequently spirits him away for tests and won’t allow her to breastfeed. Jenna begins dying early, and Rhine is convinced Vaughn is poisoning her to get rid of her. After Jenna’s death, Rhine and Gabriel escape. They take a boat from the local harbor and sail away. They are free, but still have just a few years to live. They also need to search for Rhine’s brother in Manhattan.